Comparison of craving for opioid in opioid-dependent individuals and people under methadone maintenance treatment

Azita Chehri, Fereshte Mirzaee, Habibolah Khazaie, Omid Rezaei, Hamed Ekhtiari, Azarkhsh Mokri, Behroz Dolatshahi, Payman Hassani Abharian


Background: Methadone Maintenance Therapy (MMT) is the most important treatment for opioid -dependency recurrence. The aim of this study was to compare the craving level in opioid-dependent individuals and people under methadone maintenance therapy.

Methods: In this case – control study, 120 men with opioid dependency were   selected through  cluster sampling method. They were divided into two groups, 60 people in opioid-dependent group and 60 people in MMT group. Both groups were matched    for age, sex, marital status, education, duration of opioid dependency and method of consumption. Then, they completed INCAS Substance Abuse Profile (ISAP), opiate withdrawal symptoms checklist, self–report of craving, Desire for Drug Questionnaire (DDQ), Obsessive Compulsive Drug   Use Scale (OCDUS) and visual cue-induced craving questionnaire. Data were analyzed by SPSS 15 using t-test and ANOVA.

Results: Mean craving for drug significantly was lower in MMT group comparing opioid-dependent group (P<0.01).

Conclusion: Methadone Maintenance Therapy decreased the craving for drugs and substances This can have an important role in relapse prevention.



Keywords: Drug craving, methadone maintenance treatment, opioid


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